Spatial Transcriptomics Analysis of Tumor Immune Exclusion
Visium HD pipeline for identifying CAF-mediated T cell exclusion signatures in lung squamous cell carcinoma. Identified 8 candidate genes. Manuscript in preparation.
Projects
This page separates current research-level work from earlier academic coursework, helping supervisors and collaborators quickly assess the projects most relevant to my PhD trajectory in AI for healthcare.
Tier 1
Visium HD pipeline for identifying CAF-mediated T cell exclusion signatures in lung squamous cell carcinoma. Identified 8 candidate genes. Manuscript in preparation.
Benchmarked AB-MIL, CLAM, Trans-MIL, and foundation models for homologous recombination deficiency detection. Achieved AUC 0.78 on breast cancer whole-slide images.
ArXiv preprintnnU-Net pipeline for automated echocardiogram segmentation. Dice scores: LV endocardium 0.94, LV epicardium 0.91, left atrium 0.93.
XGBoost pipeline integrating DNA methylation, CNV, mRNA, and miRNA data for breast cancer subtyping. Balanced multiclass accuracy: 0.90.
Tier 2
Comparative study of statistical and deep learning approaches for MRI brain tissue segmentation, including U-Net, LinkNet, and nnU-Net.
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Comparative evaluation of intensity-based and deep learning methods for inspiratory and expiratory lung CT registration using COPD image data.
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Transfer learning and ensemble modeling for automated skin lesion classification in a challenge setting.
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Unsupervised cluster-based segmentation of MRI brain tissues using EM and Gaussian mixture modeling, with preprocessing for improved robustness.
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Atlas-based brain tissue segmentation with analysis of affine and bspline registration strategies for improved alignment and segmentation quality.
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Machine learning workflow for breast mass detection, segmentation, and classification from mammographic images.
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Comprehensive analysis of transfer learning and machine learning techniques for clinically relevant skin lesion diagnosis.
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Classification of Alzheimer's disease, mild cognitive impairment, and control groups using MRI and gene expression data with feature selection.
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